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Therefore, further large-scale clinical studies must be carried out to evaluate the dosage and duration of therapy with these phytochemicals and herbal drugs individually and in combination with other drugs to treat PCOS

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We showed that MAPL, a SUMO E3 ligase present in mitochondria, can promote the SUMO1 modification of Drp1, facilitate its mitochondrial translocation and induce detrimental fission, leading to mitochondrial dysfunction, NPC apoptosis, and IVDD