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Participants demonstrated measurable increases in skin density and thickness, as determined through ultrasound imaging and histological analysis of skin biopsies

15 Injection site preparation & antisepsisBest-practice guidance on skin antisepsis and air-drying before subcutaneous injection

While the findings were consistent with trazodone being the least likely medication of abuse, it was proven that trazodone is commonly abused in combination with other drugs.[2] Long-term substance abuse of any kind can lead to the development of a dependence that causes withdrawal symptoms when a person stops using the drug