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Elevated hemoglobin has several causes, but its usually the result of these two mechanisms: An increase in red blood cell production

Process Biochem 48:12121215

These observations would indicate that IL-1ra deficiency reduced intrahepatic expression of CYP1A2, CYP2E1, and CYP3A11, the enzymes that could generate NAPQI, a toxic metabolite crucially involved in APAP-induced liver injury