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This led on to methods that require alkylation of the reactive sulfur atom as the trapping reaction 28

Diabetic retinopathy Chronic hyperglycemia can damage blood vessels in the retina and cause a potentially sight-threatening condition called diabetic retinopathy (83)

Autophagy and Cardiometabolic Diseases: Academic Press

The first incorporates GSH into the mitochondria by inorganic phosphate exchange and the second by exchange of 2-oxoglutarate (27, 28, 64) (Figures 2, 4)