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This positions FOXO4-DRI within advanced molecular longevity research rather than endocrine or metabolic peptide categories

Promising approaches include: Integration with immune checkpoint inhibitors and pyroptosis-released DAMPs enhances dendritic cell maturation and CD8 T cell infiltration, converting immunologically cold tumors into hot microenvironments to potentiate PD-1/PD-L1 blockade efficacy [7]

Despite rapid advances, the current understanding of proteostasis remains fragmented, with most studies historically examining individual pathways or organ systems in isolation