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Specifically, analyzed were the affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete, or incomplete infarcts (10% of the area affected)

Specifically, the combination significantly reduced TGF--induced ROS generation in HSCs and attenuated the nuclear translocation of SMAD2/3, key mediators of pro-fibrogenic and inflammatory signaling