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Symptoms of vitamin B-12 deficiency include: Fatigue Difficulty concentrating Decreased mood Loss of appetite Poor memory Constipation Higher-risk groups for vitamin B-12 deficiency include people with intestinal disorders such as Crohns or Celiac disease, as well as those who suffer from muscular degeneration, Lou Gehrigs disease or diabetes

It is instrumental in the removal of waste and fat from the liver and also contributes to cognitive functions

Chronic high-dose pyridoxine can cause sensory neuropathymanifesting as numbness, tingling, or gait instabilityemphasizing the need for appropriate dosing and periodic reassessment