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Most studies reported reduced cell viability and/or increased pro-inflammatory mediators, although the study design did not include measurement of flavoring agent and therefore, more work may be needed to prove an association (Yu et al., 2016

The chromatographic columns were a DB-5MS (60 m0.25 mm0.25 m) in the first dimension (1D) and DB-17MS (0.85 m0.25 mm0.15 m) in the second dimension (2D)