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Later, another study showed that a Parthenolide (PTL)-derived drug DMOCPTL directly bound to the GPX4 active site (selenocysteine 46), and led to GPX4 ubiquitination in triple-negative breast cancer cells ( Discovering the E3 ligase is also very important for understanding the regulatory mechanisms of protein ubiquitination

Store in a cool, dry place, protected from moisture, heat, and direct sunlight

For instance, the incidence of ibutilide-induced long QT syndrome is higher in females compared to males

The prognosis for unresectable or metastatic CCA remains dismal, with median survival limited to approximately 1 year [5]