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Whereas proper internal duct development is dependent on testosterone as the intracellular mediator, development of the urogenital sinus and tubercle into the external genitalia, urethra and prostate requires conversion of testosterone to dihydrotestosterone (DHT) by the isoenzyme 5-reductase-2

Similarly, earlier studies led by Sikiric and colleagues in the 1990s suggested safety and benefit in gastrointestinal conditions such as ulcerative colitis, but these reports were published only in abstracts or local conference proceedings, with no independent replication or peer-reviewed validation

"The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review"

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