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Evidence showed that excess intracellular hydrogen peroxide regulates the expression of various NF-B component proteins, and the alterations in the composition or quantity of the NF-B dimer can change down-stream target gene expression, and conduce to the upregulation of pro-inflammatory genes and a pro-apoptotic environment (Li et al., 2001

Pores appear smaller The skin looks clearer since the first use

In addition, pyruvate, a key glycolytic metabolite generated by pyruvate kinase muscle 2 isoform (PKM2), directly supports the DDR by facilitating -H2AX loading through the FACT (facilitates chromatin transcription) complex, thereby promoting DNA repair efficiency and conferring radioresistance [75]