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However, ninjurin-1 (NINJ1) -dependent lysis could be a driver following ferroptosis induction by promoting plasma membrane rupture and release of damage-associated molecular pattern molecules (DAMPs) during ferroptosis [71]

Twenty-two patients were enrolled in the study and were assigned to one of five cohorts receiving a single IV infusion of pegadricase (0.1, 0.2, 0.4, 0.8, or 1.2 mg/kg) (Supplementary Figure 1)