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Sudden increases in workout intensity or poor recovery between sessions can overload connective tissue

Two main strategies informed by the NMDA-R hypofunction model have been systematically pursued: potentiation of the glycine NMDA-R site in add-on RCT targeting persistent negative and cognitive deficits (e.g., glycine, D-serine, sarcosine)

The synergistic effect of nutritional-related metabolic syndrome on OA Beyond obesity alone, the constellation of nutrition-related metabolic syndrome (MetS) components including insulin resistance, dyslipidemia, and hyperglycemia, synergistically exacerbates OA progression through interconnected pathways

Systemic steroids are more likely to cause weight changes, but inhaled corticosteroids generally have minimal impact on weight when used at recommended doses