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E12 embryos: n = 12 Slc25a39 fl/fl or Slc25a39 fl/- , n = 7 ErGFP-cre +/- Slc25a39 fl/- , n = 4 ErGFP-cre +/- Slc25a39 fl/fl

Muscle growth can be induced by insulin-like growth factor (IGF), and mothers against decapentaplegic homolog 3 (MSTN-Smad3) plays a negative regulatory role in muscle growth

In our study, after 24 weeks of treatment, L-glutamine did not cause a reduction in hemolysis markers nor improvement of hemoglobin level, as there was no difference between the two groups except at week 12, the reticulocyte count was higher in those on SOC