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NEJMcp1113996 PMid:23301732 Narang N, Sharma J

Clinics generally advise against starting treatment for anyone who: Is pregnant Has a personal or family history of thyroid cancer Has a history of multiple endocrine neoplasia (MEN) syndrome BMI and health history serve as a useful starting point for this evaluation, not an absolute cutoff, since metabolism and overall wellness also weigh into a provider's decision

This is increasingly important as more trials move into decentralized, at-home settings without clinical supervision, where patients must rely on the device design and labelling to use it correctly