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226 Similarly, mutant SOD1 aggregates within the mitochondrial intermembrane space, disrupts mitochondrial retrograde transport, and sequesters OPTN, suppressing mitophagosome formation

Immunofluorescence (IF) studies indicated that those transplanted GMSCs integrated into the wall matrix of NPs and localized in the peripheral areas outside of the injured nerves as recognized by the positive expression of human nuclei, whereas only about 5% of them were positively stained for the active form of caspase-3 (Additional file 1: Fig

As a sensitivity analysis, a stricter improvement definition of MELD-3 2 (at least two-point decrease, representing a clinically meaningful change) was applied

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