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We identified several factors associated with the presence of a positive test result which are readily apparent and could help inform real-time clinical decisions

Li Y, Calfa G, Inoue T, Amaral MD, Pozzo-Miller L (2010) Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons

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The loss of the suprachiasmatic nuclei ability to resynchronize in response to environmental cues adds to these factors, reducing the amplitude and synchrony of clock genes expression in key regions such as the prefrontal cortex and hippocampus, which is associated with cognitive deficits and increased susceptibility to neurological insults (He et al., 2023)