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Danggui Buxue decoction can reduce the content of ceramides (Cers), phosphatidylethanolamine, and phosphatidylcholine in the kidneys of mice by downregulating the transcription levels of Degs2 and Cers, reducing lipid accumulation, promoting Akt phosphorylation, and alleviating lipid accumulation as well as renal injury [156]

Additionally, medications such as saxagliptin and metformin have demonstrated effectiveness in regulating -cell function by reducing inflammation in newly diagnosed T2DM patients with PCOS (74).These findings suggest that the crucial role of pancreatic inflammation and -cell dysfunction in PCOS-related metabolic complications and highlight the need for targeted interventions that can improve -cell function and reduce inflammation

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We propose a model to illustrate the bifunctional potential of GSTP1 in protecting cells from chemically reactive metabolites targeting the ER