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Microbially derived indoles (indole, indole-3-acetic acid/IAA, indole-3-propionic acid/IPA, indole-3-lactic acid/ILA) critically influence CRC progression: ILAthe most extensively studied anticancer indoleactivates CD8 + T cells by enhancing dendritic cell IL-12 production via histone modification and chromatin accessibility (316), promotes effector molecule release by inhibiting the cholesterol metabolism gene Saa3 in CD8 + T cells (316), and reduces CD86 + proinflammatory macrophages via AhR/p-AKT/IL-1 signaling (374)

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