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IV NAD+ infusions are typically administered over 2-4 hours due to potential flushing and nausea with rapid infusion

Due to problems with data at some of the trial centers conducting the trial, the company is taking extra time to analyze the data and is expected to share results this year

(see Table 17)

Finally, medicinal chemistry should advance analogs with improved stability and minimized promiscuous protein binding, specifically aiming to reduce marrow suppression and mitochondrial liabilities while retaining on-lesion potency (103)