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This pathway makes the endothelial cells change on many levels

Aided Drug Des 265 Sadigh-EteghadS.SabermaroufB.MajdiA.TalebiM.FarhoudiM.MahmoudiJ

50 Annular stabbing with needles in animal model consistently triggers disc degeneration, characterized by loss of disc height, hydration and proteoglycans and by the expression of inflammatory, catabolic and fibrotic proteins