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These experiments suggest that the ferric reductase activity of SpNOX might not be physiologically relevant but rather an effect of the promiscuity of SpNOX for the final electron acceptor in vitro

The effect of PDT on the oral microbiome has been poorly studied, and the available evidence suggests that PDT reduces clinical infections caused by drug-resistant Gram-positive and Gram-negative bacteria (Carpenter et al., 2015)