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Moreover, other genetic traits, such as the functional deficiencies in cobalamin-dependent methionine synthase described above, could contribute to an increased relative risk of cardiovascular disease, but their respective contributions are not yet determined

The abnormal activation of these channels leads to the influx of Ca 2+ into the cell, which plays a critical role in the imbalance of the action potential and finally helps in the triggering and propagation of seizure

As an illustration of this complexity , in one clinical trial, it was found that antioxidant supplementation was associated with a reduction in cancer incidence in men after a follow-up of 7.5 years 91, but such antioxidant supplementation may only have beneficial effects on cancer incidence in healthy subjects with low baseline antioxidant levels 83, 92

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