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In vitro studies using MDCK cells (a model of intestinal epithelial permeability) demonstrated that PLGA nanoparticles significantly enhanced cellular uptake and transport of puerarin across cell monolayers, achieving a permeability coefficient value of 2.83 0.27 10 5 cm/s, which was significantly higher than that observed for free puerarin (0.38 0.07 10 5 cm/s)

Liposomal glutathione and sublingual formulations have been developed specifically to bypass digestive breakdown

A multicenter Phase III clinical trial confirmed that elagolix significantly reduces menstrual blood loss associated with uterine fibroids, with efficacy unaffected by age, body mass index, ethnicity, baseline bleeding volume, or fibroid location [160]