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Elevated expression of LFABP in ibuprofen treated male and female livers together with increased levels of H 2 O 2 (a byproduct of fatty acid -oxidation) is indicative of increased fatty acid metabolism

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11 The inhibition of EGFR signaling alone in a PH model has been shown to only delay liver regeneration.30, 32 This finding indicates that the dynamics and mechanisms of liver regeneration are very different in the APAP-induced ALF model as compared with PH, and that liver regeneration after APAP overdose is more critically dependent on EGFR activation

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