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PLoS One 7:441448 Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology

One new hypothesis is that mitochondrial ROS generated during hypoxia promote the oxidation of cysteine residues within PHD2 resulting in oxidative PHD2 homodimerization and inactivation, leading to HIF- protein stabilization 26

Oct 2017;11(3):156-165

The substances under review are among those that former president Joe Biden's administration restricted from compounding, notably over a lack of human clinical trial data