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However, rtPA therapy can dramatically enhance the risk of hemorrhagic conversion and BBB permeability

Microglia express multiple glucose transporters, including GLUT1, 3, 4, 5, 6, 8, 9, 10, 12, and 13, as well as high levels of hexokinase 2 (HK2), which collectively ensure sufficient glucose influx for their metabolic needs (Baik et al., 2019

Constitutive activation of NF-B in myeloid cells, as a result of IB deletion using the LysM-Cre system, causes more severe CNS inflammation and clinical scores in myelin oligodendrocyte glycoprotein-induced EAE, 121 whereas myeloid cell-specific deletion of IKK inhibits EAE induction associated with impaired generation of inflammatory Th1 and Th17 cells

These effects included downregulation of senescence-associated biomarkers, SASP suppression, and muscle fiber hypertrophy