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In response, GSH, of the antioxidant defense system, participates in the detoxification of toxic HMs through three possible pathways which include, direct scavenging of ROS in the AsA-GSH cycle, HM chelation through the synthesis of phytochelatins (PCs), and conjugation of HMs catalyzed by glutathione S-transferase (GST

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10.1016/j.numecd.2024.10382839809641 163 Nardi V, Franchi F, Prasad M, et al

Micro-CT and histological staining of knee joints show that BCA prevents cartilage iron deposition and reduces KOA severity in iron-overloaded mice, suggesting new therapeutic avenues for KOA (171)