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CYP3A4 is thought to be the most important P450 enzyme due to its high capacity, abundance, and versatility.1 It accounts for 30% of the total liver P450 enzyme content7 and is so highly active that certain susceptible drugs can be 85% metabolized immediately following absorption, with only 15% of the drug molecules ever reaching their target organs

Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing

The clinical potential of GPx4 as a tumor Achilles heel needs to be unlocked through precise intervention strategies in the future to facilitate the translation from pathogenesis to therapeutic innovation

This tripeptide plays essential roles in cellular protection, detoxification, and immune function