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In such a study (16-week randomized, double-blind, placebo-controlled), 204 individuals with obesity but not diabetes were treated with self-administered subcutaneous injections of pramlintide (nonforced dose escalation 240 g) or placebo three times a day, 15 minutes before meals without concomitant lifestyle intervention (200)

doi: 10.1590/fst.02818 3

Inflammation and fibrosis can affect tubulo-interstitial lesions, and both glomerular and interstitial injuries will development of CKD