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The mitochondrial origin means MOTS-c acts at the cellular energy level in a way no GHRH analog, tissue-repair peptide, or cognitive peptide does

Third, it stimulates glucose-dependent insulin secretion from pancreatic beta cells while suppressing inappropriate glucagon release improving glycemic control without significant hypoglycemia risk

It can also interfere with levodopa therapy if levodopa is taken without carbidopa, as vitamin B can diminish levodopas therapeutic effect