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In addition, the presence of ferroptosis and heat shock protein binding suggests that it may play a role by affecting iron-dependent cell death and stress response pathways (Fig

To ascertain a comprehensive role of the UPR in cystine uptake inhibition-induced ferroptosis, we examined the status of the three canonical UPR pathways: (1) IRE1-XBP1s, (2) PERK-ATF4-eIF2 and (3) ATF6 in both MDA-MB-231 and Panc-1 cells upon erastin treatment or cystine starvation

In a key study of 1000 drug-like small molecules, less than 10% accumulated to concentrations greater than 50% of that present in the medium [12]

Liang Y, Gao Y, Wang W, Dong H, Tang R, Yang J, et al