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In female rats given daily subcutaneous doses of 0.01, 0.03, or 0.1 mg/kg, beginning 15 days before mating and continuing through gestation, parturition and lactation, dystocia and periparturient mortality were observed in pregnant rats allowed to deliver starting at 0.01 mg/kg/day (0.1 times the human 5 mg intravenous dose, based on AUC)

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By engineering an analog that binds these proteins poorly, researchers created a form of IGF-1 that remains largely free and therefore available to engage the IGF-1 receptor over a much longer window