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Please refer to the CY 2024 PFS final rule (88 FR 79032 through 79033) for more detailed information

The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis

It is also used to treat vernal keratoconjunctivitis (allergic eye condition) and signs and symptoms of dry eye disease.

The efficacy of Antil has also been demonstrated in drug allergies, anaphylactic shock, laminitis, bloat in ruminants due to histamine atony of the rumen and in the treatment of acute septic metritis in cows in conjunction with anti-bacterial therapy