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Since TLR4 dimerization mediated by LPS is necessary for the activation of downstream signaling pathways, including NF-B, 6-shogaol blocks this process and prevents NF-B activation (231)

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The lower molecular weight of Hb dimers also facilitates the translocation of Hb from the circulation to the vasculature and other tissues sensitive to Hb oxidative reactions (Figure 1)