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It remains to be demonstrated if such dosing applied in a life-threatening context could be extrapolated to routine use exceeding what the Institute of Medicine (IOM) defined upper intake level for adults, above which the risk of hypercalcemia and other adverse events (not shown in the Calgary study) [96] may increase [58]

[DOI] [PubMed] [Google Scholar] 207.Nakamura T., Hipp C., Santos Dias Mourao A., Borggrafe J., Aldrovandi M., Henkelmann B., Wanninger J., Mishima E., Lytton E., Emler D., et al

Recent single-cell and single-nucleus transcriptomic studies have already delineated more than nine transcriptionally distinct astrocyte clusters, underscoring both the complexity of astrocytic heterogeneity and the inadequacy of traditional binary classification schemes 20,61

Benveniste MF, Rosado-de-Christenson ML, Sabloff BS, Moran CA, Swisher SG , Marom EM