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Just as low intracellular glutathione levels (as observed in many cancer cells) can decrease antioxidant capacity 9 , elevated levels of glutathione are shown to increase antioxidant capacity 10 and improve resistance to oxidative stress

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The data suggest an independently regulated nuclear GSH pool and confirm that fluctuations of nuclear GSH are dependent on cell proliferation

Akt may drive TCA cycle flux and lipid biosynthesis by directly phosphorylating and activating ATP-citrate lyase, which protects tumor cells against chemotherapy drugs toxicity (Robey and Hay, 2009)