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22 The GI microbiota is thought to be less diverse than that of soil environments, 23 but these findings nevertheless suggest that the GI bacteria may have a significant, but underestimated, capacity to metabolise environmental chemicals

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However, the physicochemical diversity of these molecules, ranging from small polar metabolites to hydrophobic steroids, requires diverse sensing strategies [15,16]

GST family members (MGST2 and 3, and GSTM4), as well as LTC4 synthetase, catalyze the conjugation of GSH to arachidonate epoxide, which is formed by 5-lipoxygenase [23]