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2008 May;42(5):661-9 [PubMed Citation] Summary of the NIAID Expert Panel Review on Medical Chemical Defense Research, March 19, 2003, Bethesda, MD (NIH/NIAID) Sutter M, Tereshchenko N, Rafii R, Daubert GP

Moreover, lactate stimulates CAFs to upregulate IL-6 expression, and IL-6, in concert with lactate, inhibits the activity of cytotoxic immune cells, further enhancing tumor immune evasion [78]