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This so-called autocrine loop of ROS by HSCs is regarded as mechanism corresponding to the autocrine loop of TGF- which HSCs produce in response to this cytokine with an increased collagen expression in the injured liver (Itagaki et al., 2005)

Inhibition of TLR4 signaling impedes tumor growth in colitis-associated colon cancer

Two studies on athletes showed that exogenous administration of melatonin can alleviate oxidative stress, inflammation, and muscle damage, and might improve exercise performance 60,61

Toll-like receptor 3 agonist poly I:C reinforces the potency of cytotoxic chemotherapy via the TLR3-UNC93B1-IFN- signaling axis in paclitaxel-resistant colon cancer