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For instance, antioxidants have been shown to protect zebrafish lateral-line hair cells from ototoxic damage, and mitochondrial transplantation, a novel form of therapy, enhances bioenergetics and mitigates oxidative stress-induced apoptosis in auditory cells (Holmgren and Sheets, 2020

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In addition, most recently, another di-substituted hydroxylamine, named OT551, able to cross blood-brain barrier (BBB) and inhibit OS and inflammation, has been developed and has shown efficacy in a phase-II clinical trial on age-related macular degeneration