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While traditionally regarded as a vitamin B clearance enzyme, over the past decade NNMTs role has expanded dramaticallyto include reprogramming onecarbon metabolism, impacting NAD levels, DNA/histone methylation, and even tumor progression and angiogenesis

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Several studies have shown coordinated overexpression of GCLC and MRP in drug-resistant tumor cell lines, in human colorectal tumors and in human lung cancer specimens after platinum drug exposure (Kuo et al., 1998