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Disclosures: Min Luo: Nothing to Disclose, Huan Deng: Nothing to Disclose, Lingyu Song: Nothing to Disclose, Yaping Shi: Nothing to Disclose, Hua He: Nothing to Disclose, Dachuan Cai: Nothing to Disclose, Xiaofeng Shi: Nothing to Disclose, Yongjian Liu: Nothing to Disclose 685 PEOPLE OF AFRICAN/AFRICAN AMERICAN ANCESTRY HARBOR FEWER LIVER DISEASE-RELATED RISK ALLELES THAN EUROPEAN (WHITE) ANCESTRY Ning Ma 1 Myvizhi Selvan 1 Daniela Sia 2 Meena Bansal 3 Richard Sterling 4 Zeynep Gm 2 Andrea Branch 3 , 1 Icahn School of Medicine at Mount Sinai, 2 Icahn School of Medicine Mount Sinai, 3 Icahn School of Medicine at Mount Sinai (ISMMS), 4 Virginia Commonwealth University Background: African Americans with hepatocellular carcinoma (HCC) tend to have less advanced cirrhosis at diagnosis than other patients but exhibit more aggressive forms of HCC