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However, the increase in mGluRs-dependent signaling in the mouse model of FXS was not confirmed in human-based models, and clinical trials with mGluR inhibitors failed to produce a therapeutic effect in FXS patients [331]

2) to specifically link the results to the UN Sustainable Development Goals (SDGs), thus showing the potential impact of implementing policies towards risk reduction or elimination in light of global health improvement

doi: 10.3389/fvets.2025.1632022, 2

440 SCFA, as the main metabolite produced by the fermentation of dietary fiber by intestinal microorganisms, can normally pass through the BBB, provide energy substrates for brain cells, and maintain mitochondrial function