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All results from the literature refer to cytotoxic activities in different tumor cell lines (A549, MCF-7, SKOV3, PC-3, HepG2, U937) but not to animal experiments or human studies (Chang et al., 2015)

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Depletion of glutathione and inadequate glutathione system Regulatory T-cell failure Breakdown of barrier systems NF-kB dysregulation/chronic inflammation Impaired hepatic biotransformation All of these systems are compromised to some degree in loss of chemical tolerance and management of this condition must include assessment of all these areas and address all physiological imbalances that are identified or suspected

This however, is still the optimal circumstance for healing to take place, because the sheath that provides circulation and nutrients is still intact