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Tumor necrosis factor-alpha (TNF-)and Interleukin-1 (IL-1) as well as other cytokines involved in homeostasis or neuroinflammation and illness, are produced by microglia [34]

For example, the lack of certain symbiotic species (e.g., Faecalibacterium prausnitzii ) is said to be responsible for the recurrence of Crohns disease as mice supplemented with this organism experienced reduced inflammation after inducing colitis chemically (Sokol et al., 2008)

SIRT3 activator honokiol inhibits Th17 cell differentiation and alleviates colitis