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Laboratory studies support this notion: in vitro cultured microglial cells, when exposed to FeCl2, underwent activated morphological changes [188]

Glutathione helps regulate cellular proliferation (i.e., the building of new cells) and apoptosis (i.e., disposal of old, dying cells)

The average change in 3-month LFI was -0.19 (improvement in frailty) with the largest increase occurring from 3 to 6 months (-0.35)

Based on the effectiveness of ferroptosis and pyroptosis combined induction, in vivo experiments have confirmed that dual-induction nanoparticles demonstrated ideal anti-cancer effects in a xenograft mouse model, suggesting that the combined induction of ferroptosis and pyroptosis may be an effective and promising cancer treatment approach (179) ( Figure 8D )