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Glutathione production by recombinant GCI strains engineered in l-Ser biosynthetic pathway L-Ser biosynthesis occurred through the l-Ser biosynthetic pathway from its precursor of 3PG, consistent with continuous reactions catalyzed by Ser2, Ser1, Ser3, and Ser33 (Fig

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Combined BRAF and MEK inhibitors, as compared with BRAF inhibition alone, provided remarkable response rates in melanoma, delayed the emergence of resistance, and reduced toxic effects in patients with BRAF V600E -mutated melanoma ( V600E -mutated melanoma cell lines (conventional and PDCLs) responded distinctively to PLX4032 (also known as RG7204 or RO5185426) ( V600E mutant cells

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