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Because a specific central carbon metabolic transition occurs simultaneously during the epigenetic transition from stem cells to somatic cells or vice versa, metabolism has an important role in determining the epigenetic landscape that influences cell fate

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(6) And while 13% of the study participants had negative side effects from turmeric, most studies, including a 2025 umbrella meta-analysis, suggest that turmeric is generally safe for healthy people

121,122 Estrogen receptor 1 (ER1) and estrogen receptor 2 (ER2) are transcription factors that are members of the NR family