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As a consequence, this triggers the generation of lipid peroxides, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which are extremely toxic to the cell because they initiate a newly characterized form of cell death termed ferroptosis (27), which is a key phenomenon in the pathogenesis of neurodegenerative diseases, such as Parkinsons disease (PD) (28)

An optimal balance in the consumption of fatty acids includes 35% polyunsaturated fatty acids and 65% saturated fatty acids, and the appropriate proportion of PUFA to maintain membrane balance is 50% omega3 with 50% omega6

Yu NN, Tan MS, Yu JT, Xie AM, Tan L

(1997): On the virtual existence of superoxide anions in mitochondria: thoughts regarding its role in pathophysiology